Hendrick Janse Oothout was born about 1663. He was the second son of New Netherland pioneers Jan Janse and Hendricktie Van Ness Oothout. His father was a brewer in Beverwyck and then Albany.

In April 1684, he married Albany native Catharina Douw. By 1705, their eleven children had been baptized at the Albany Dutch church where both parents were members and regular baptism sponsors.

Hendrick Janse lived in Albany, on an inherited countryside farm, and, for a time during the 1690s, in New York City. Like his father, he was a businessman, brewer, and landholder. His father-in-law was similarly prominent and a brewer as well. Hendrick Janse was annually elected assistant alderman for the first ward from 1698 to 1704. During that time, he was active as a contractor, surveyor, and justice. In 1699, he joined his neighbors in pledging allegiance to the king of England. His first ward home was taxed as those of other substantial community leaders. In 1715, his name appeared on an Albany militia roster. In 1720, he was listed among the freeholders living in the first ward.

Hendrick Janse Oothout filed a will in October 1738. Seven surviving children but not his deceased wife were named in that document. At that time, he identified himself as a yeoman of Rensselaerswyck. His estate included a lot in Albany, pasture land south of the city, a farm called "Turkeye" on the west bank of the Hudson where he was living, woodlands, four islands in the Hudson, and personal property. He died in July 1739. His will passed probate in April 1740.

Sources: The life of Hendrick Janse Oothout is CAP biography number 428. This profile is derived chiefly from family and community-based resources.